If you are taking 500 mg or more vitamin C daily, there is something you need to know. Vitamin C (in excess) can become a toxin that can lead to kidney stones, arthritis, other pain conditions, and perhaps, compromised brain function. For decades we have been told that vitamin C is good for us and may help prevent colds. But too much of a good thing can make trouble. (Research has not been able to confirm the theory that vitamin C supplements help to prevent colds unless you routinely engage in physically demanding work or endurance sports.)
The body tends to metabolize excess vitamin C into a corrosive acid called oxalic acid. This acid immediately steals minerals like calcium as it becomes oxalate. As the kidneys remove oxalate from the blood, calcium oxalate can grow into crystals in the kidneys or elsewhere in the urinary tract causing painful stones. Over time, if the kidneys are forced to handle excessive amounts of oxalate everyday, kidney failure is likely. This is how taking 500 mg or more of vitamin C can promote a loss of kidney function. Perhaps the modern habit of taking extra vitamin C is contributing to the rising rates of kidney stones. One estimate suggests that half of us will get a kidney stone in our lifetime.
Oxalates in the body that are not removed by, or stuck in, the (perhaps struggling) kidneys can get lodged in other tissues of the body and cause trouble there too. Oxalate crystals have been found in every human tissue including bones, joints, glands – especially the thyroid, blood vessels, arterial plaque, eyes, lungs, and skin. These crystals are sharp and irritating, and they may trigger an immune response and promote inflammation. They may also generate free-radicals that can damage cell membranes and damage the cell organelles, especially the mitochondria which are important energy producers.
When a cell attempts to dissolve the oxalate crystal deposits, oxalate molecules or ions may move around and trigger episodic pain or difficulty with brain and nerve functions. Sleep, concentration, memory, and thinking can all be affected by the movement of oxalates in and around neurological tissues. Likewise, bone problems and joint pain can result from calcium oxalate deposits which may become more likely when excess amounts of vitamin C are taken.
How much vitamin C is safe?
The RDA for C (ascorbic acid) is 75 mg for adult females and 90 mg for adult males. This sounds like very little, but even as little as 10 mg is enough to avoid scurvy – the vitamin C deficiency disease. A daily intake of 150-200 mg of C is considered safe for most people and is under the threshold that seems to generate additional oxalate in the body. Most people can get that much from typical diets that contain some vegetables or fruits. To illustrate the point, see the tables below. I offer two hypothetical diets: 1) a diet with many healthy fresh foods, and 2) a diet of mostly fast food. (Just major ingredients are listed in the tables.)
The diet of healthy, fresh foods listed in Table 1 is not necessarily my recommended diet, but it comes close. Notice that a lunch of beef stew with a salad composed of romaine lettuce and ¼ of a red bell pepper provides over 60 -70% of the RDA by itself. If the dressing was made with lemon juice, that would add 5 mg more and bring the vitamin C content of the lunch up to 59 – 66 mg. Add 2 sliced radishes (~4 mg vit C.) to bring the vitamin C content of lunch to nearly 70 mg (78 – 93% of the RDA). Of course, many people skip the salad option at lunch and instead select convenience foods, as in my hypothetical fast food diet in Table 2 below.
Lets a look at the diet of fast foods with no extra fruits or vegetables (Table 2) which only gets us about 25% of the RDA. The addition of just ¼ of a fresh bell pepper (38 mg C) and 1/2 cup of raw cantaloupe (23 mg C) would bring the fast-food diet up to the RDA for vitamin C. Of course, adding bell pepper and cantaloupe cannot correct the many other deficiencies and problems created by a fast-food diet.
These tables are intended to illustrate the point that vitamin C requirements can be met when fresh vegetables or citrus fruits are included in the diet. There is no need for a daily vitamin C supplement if you eat fresh vegetables daily – broccoli with dinner or a simple salad can get you there. Remember, however, that the body does not store vitamin C, so you need to eat foods with vitamin C every day. Make my favorite dressing tonight, and enjoy a delicious salad tomorrow.
There is no need for a daily vitamin C supplement if you eat fresh foods – everyday. If you do take vitamin C containing supplements or C fortified foods keep it at a safe level – which seems to be between 150 – 250 mg.
Table 1: A day with plenty of vitamin C (values from Pennington & Spungen, 2010)
Food | Amount | Vit C Content in mg |
Breakfast | ||
(Yogurt) with
Apple, unpeeled raw OR Raw blueberries |
1 medium
½ C |
0
6 7 |
Sub-total Breakfast | 6 – 7 | |
Lunch | ||
Canned beef stew | 1 C | 3 – 10 |
Salad with
Romaine Lettuce raw Red bell pepper, raw Olive oil and vinegar |
1 C
¼ of a pepper |
13
38 |
Sub-total Lunch | 54 – 61 | |
Snack | ||
Grapefruit juice, canned
1 oz. cheese |
½ Cup or 4 oz. | 37 |
Sub-total Snack | 37 | |
Dinner | ||
Clams, canned with garlic and butter, over… Spaghetti Squash, boiled Sprinkled with Lemon juice, raw Romano Cheese |
3 oz
1 C 2 tsp. 2 Tbsp. |
19
0 5 5 0 |
Broccoli, fzn, boiled, drained | 1 C (91gms) | 74 |
Sub-total Dinner | 103 | |
DAY TOTAL | 200 – 208
= 270% of RDA for females = 267% of RDA for males |
Table 2: A vitamin C deficient diet …is a diet without fresh fruits and vegetables.
Food | Amount | Vit C Content in mg |
Breakfast | ||
Sausage and Egg McMuffin | 1 McMuffin | 0 |
Sub-total Breakfast | 0 | |
Lunch | ||
Pizza | Any amount | 0 |
Bread sticks | 0 | |
Sub-total Lunch | 0 | |
Snack | ||
Crackers or chips or almonds | Any amount. | 0 |
Sub-total Snack | 0 | |
Dinner | ||
6”Subway Sub Cold Cut combo (has lettuce and tomato) |
6” | 21 |
Sub-total Dinner | 21 | |
Snack | ||
Beer | 12 oz | 0 |
Sub-total Snack | 0 | |
DAY TOTAL | 21
=28%RDA for females =23% RDA for males |
More about Vitamin C, Oxalates and Health:
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Baxmann, A. C., Mendonça, C. D. O. G., & Heilberg, I. P. (2003). Effect of vitamin C supplements on urinary oxalate and pH in calcium stone-forming patients. Kidney International, 63(3), 1066–1071. http://doi.org/10.1046/j.1523-1755.2003.00815.x
Canavese, C., Petrarulo, M., Massarenti, P., Berutti, S., Fenoglio, R., Pauletto, D., … Marangella, M. (2005). Long-term, low-dose, intravenous vitamin C leads to plasma calcium oxalate supersaturation in hemodialysis patients. American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation, 45(3), 540–549. http://doi.org/10.1053/j.ajkd.2004.10.025
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Chelsey says
Sally, this is really interesting. My mind is sort of “blown” right now!!! But every bit of this makes sense. I guess I’ll back off of the 3-4k MG of vitamin C I take a day!!
Sally K. Norton says
Chelsey, It is best to come down on your Vitamin C gradually. A sudden drop can potentially trigger a brief bit of scurvy symptoms. You can cut it in half for 3 days, and keep working down from there.
Christopher John Walden says
Hi Sally
Each morning Inhave a heaped teaspoonful of Turmeric
Ginger and a pinch of cinnamon with Manukka honey in half a cup of boiled water.
This definitely helps with my arthritic hip and dodgy knee
I also have 3500mg of vitamin c tablets spread throughout the day
I’m gathering from my brief encounter with your website that this is not good?
Can you offer any alternative suggestions for a busy entrepreneur of 67?
Kind regards
Chris J Walden (UK)
Sally K Norton says
You can look up Catherine Nelson’s article “The Essential Medicinal Chemistry of Curcumin“, which suggests that curcumin/turmeric is not especially effective in the body at doing any of the things that lab testing suggests it might. I have a blog post on Vitamin C – I’d recommend working down gradually to no more than 500mg per day by cutting your dose in half for a week or so, then cutting in half again. It will take a month or more given where you’re starting.
Check out my blog post on spices. Ginger is fine in moderation, and honey generally seems quite low.
Fiona Aedgar says
Hi Sally, thanks so much for this. I just wanted to ask you – I seem to have a vitamin C deficiency, maybe because I’m auto-immune (type 1 diabetes). Vit C supplements have helped me a lot but now I’m scared to take them. Would Vit C from fresh lemon juice be ok, or does the Vit C content still cause the oxalate issues?
Fiona
Sally K Norton says
Hi Fiona, Good question. Lemon juice is an ideal way to get needed Vit C, because it is hard to over-dose on C that way – even if you juice 6 or 7 lemons everyday. Supplements are altogether too high in C to be safe. I highly recommend that you do juice fresh lemons and drink at least 3/4 cup of juice over the course of a day. Not only do you get the needed Vit C, but the citric acid lemons provide is great for your kidneys and helps the body breakdown oxalate deposits. Lettuce and red peppers also have Vit C.